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Nerve Regeneration Research


Human Studies


Y
amada H, Yananaka Y, Orihara H & Ogawa H (1995). A preliminary clinical study comparing the effect of low level laser therapy (LLLT) and corticosteroid therapy in the treatment of facial palsy. Laser Therapy 7: 157-162.  Abstract: Seven cases of peripheral facial palsy, who were patients of our hospital’s dermatological clinic, were treated with diode low reactive-level laser therapy (LLLT) while another seven cases, who were patients of our hospital’s otolaryngological clinic, were treated with a combination therapy consisting of LLLT and corticosteroid therapy, over the past one and half years. The clinical efficacy of the two regimens has been analyzed so that the comparison could be made utilizing a separate corticosteroid therapy group as the control. Those patients who had received LLLT showed a very similar overall recovery from the palsy when compared to those treated with corticosteroid, however, those patients who had received the combination therapy showed the best recovery in the shortest period. No clinically significant adverse effect resulting from the LLLT was noted. Our results suggest that LLLT would be a suitable alternative treatment for those facial palsy patients for whom corticosteroid is not manageable, and furthermore that LLLT would be an ideal adjunctive treamtment for those facial palsy patients for whom corticosteroid therapy is manageable.
Ozen T, Gorur I and Ozturk A (2006). Efficacy of low level laser therapy on neurosensory recovery after injury to the inferior alveolar nerve. Head & Face Medicine 2(3).


Animal Studies


Byrnes, K., Waynant, R., Ilev, I., Wu, X. et al (2005). Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury. Lasers in Surgery & Medicine 36(3): 171-185.


Shamir M H, Rochkind S, Sandbank J, Alon M (2001). Double-blind randomized study evaluating regeneration of the rat transected sciatic nerve after suturing and postoperative low-power laser treatment. Journal of reconstructive microsurgery. 2001; 17 (2): 133-137.


Rochkind-S, Nissan-M, Alon-M et al. (2001). Effects of laser irradiation on the spinal cord for the regeneration of crushed peripheral nerve in rats. Lasers in Surgery and Medicine 2001, 28 (3): 216-219.

Rochkind S, Shahar A & Nevo Z (1997). An Innovative approach to induce regeneration and the repair of spinal cord injury. Laser Therapy 9 (4): 151.


Ohno T (1997). Pain suppressive effect of low power laser irradiation. A quantitative analysis of substance P in the rat spinal dorsal root ganglion. J Nippon Med Sch. 64 (5): 395-400. (In Japanese with English abstract).


Khullar SM, Brodin P, Messelt EB, Haanaes HR (1995) The effects of low level laser treatment on recovery of nerve conduction and motor function after compression injury in the rat sciatic nerve. European Journal of Oral Science, 103:299-305.

Tsuchiya K et al. (1993).
Diode Laser Irradiation Selectively Diminishes Slow Component Of Axonal Volleys To Dorsal Roots From The Saphenous Nerve. Neuroscience Letters, 161: 65-68.


Anders J J (2007). Light Therapy - A Non-Invasive Emerging Therapy for Treatment of Spinal Cord Injury. Lecture given at Working 2 Walk Science Symposium, April 22, 2007 in Washington DC.


Midamba E D & Haanaes H R (1993) Low reactive-level 830 nm Ga Al As diode laser therapy (LLLT) successfully accelerates regeneration of peripheral nerves in human. Laser Therapy 5:125.

Laser Research